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Florence Computational Biology Group

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Our research

Our research is focused on the understanding of complex cellular phenotypes through the use of computational modelling and experimental procedures. We are currently developing models and experiments to understand the role of metabolic and regulatory networks in the establishment of microabial cell-to-cell aggregation and pathogenic phenotypes (including virulence and antibiotic resistance).

To do this, we develop computational tools and make use of already established approaches (e.g. Constraint-based metabolic modelling and NGS and microbiome analysis pipelines)

Our research is focused on the understanding of complex cellular phenotypes through the use of computational modelling and experimental procedures.

We are currently developing models and experiments to understand the role of metabolic and regulatory networks in the establishment of microabial cell-to-cell aggregation and pathogenic and social behaviours (including quorum sensing, virulence and antibiotic resistance). We are also interested in the interactions that bacteria establish with other organisms (see here and here) and in the way they approach and consume complex nutritional sources.   

                        

 

To do this, we develop computational tools and make use of already established approaches (e.g. Constraint-based metabolic modelling and NGS and microbiome analysis pipelines)

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